Homologous chromosome pairing in wheat. B The number of RAP1 signals was used to determine the extent of telomeres association in squashed spermatocytes of wild-type mice at meiotic prophase I. Cell squash preparations were used as these, in contrast to surface chromosome spreads, allow staining of tubulin, which can be used as a marker for nuclear envelope dissolution and meiotic spindle assembly.
Trends Genet — The discovery of a limited number of mutations in FLNA as the cause of the condition has clarified the molecular basis of the disorder, but only a very small number of severely affected males have been reported with MNS. We describe familial occurrence of a phenotype resembling vascular EDS in a mother and her two sons, who all died at an early age from arterial ruptures.
Nature —U View Article Google Scholar 5. Thus, while sex determination is generally characterized by diversity and turnover, some sex-determining systems appear to be more evolutionarily stable than others . Monogeny: all offspring of a particular individual female are either exclusively male or exclusively female e.
Are you sure you want to Yes No. Result of nondisjunction during Meiosis Short stature, skin flaps on back of neck, Mutations are known, however, that override sex determination Table 1 suggesting that the conservation is not due to a lack of genetic variation. But for a lot of the following syndromes, problems may only appear at puberty or later infertility.
An equilibrium infection frequency can be maintained under these circumstances equation 6 ; allowing the long-lasting co-existence of infected and uninfected females and the evolution of conflict between the nuclear and cytoplasmic genes.
We then consider a seemingly ideal protocol that avoids this bias-mutagenesis of virions-but find that it is hampered by other problems. This mutation causes a frame shift, resulting in aberrant amino acid sequences at the C-terminal.
Lethal mutagenesis: targeting the mutator phenotype in cancer. Thus the clustering of kinetochores in these spreads coincides with movement towards the SPBs.
Primer sequences and co-ordinates are listed in Table S2. To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. The association of Zip1 with centromeres as cells exited pachytene was monitored using immunofluorescence microscopy.
Spreads were categorized according to the GFP inter-dot distance: paired 0—0. Based on these similarities, we propose that also in mice centromere pairing may promote proper segregation of homologous chromosomes.