A two-tailed t-test was utilized to determine the statistical difference between control and CKAP2-depleted cells. In order to investigate the possibility that CKAP2-depleted cells were utilizing a kinetochore- or chromatin-driven microtubule polymerization mechanism to overcome centrosomal nucleation difficulties, we assessed the localization of the dispersed microtubule filaments in relation to kinetochores.
These observations prompted us to assume that CKAP2 does not affect dynein-dependent transport of spindle pole organizing proteins. The proper process of distributing the correct number of chromosomes into two daughter cells during mitosis depends on numerous proteins, including centrosomal components and those responsible for the organization of the spindle poles.
Carla Easter, Ph. Typically in mammals, the gender of an organism is determined by the sex chromosomes. Females have two X chromosomes in their cells, while males have both X and a Y chromosomes in their cells. In the case of humans, this happens to be the X and the Y chromosomes.
And what's also very fascinating about this is, I don't think it's really been determined exactly what it is on each of those chromosomes that make someone male or female in particular.
This centromere can be in the middle of the chromosome or closer to an end. The final pair of chromosomes are called the sex chromosomes and determine gender, among other traits. A chromosome centromere is the region of the chromosome where the chromosome attaches to its matching homolog during replication.
Typically in mammals, the gender of an organism is determined by the sex chromosomes. Humans and most other mammals have two sex chromosomes, the X and the Y. Cold Spring Harbor Laboratory.
J Cell Sci : — No significant differences in growth activity are observed. One of the principal molecular components in tethering and focusing spindle microtubules at the poles is NuMA . The histogram represents the percentage of remaining viable cells relative to shCTL for each experimental group for six biological replicates.