Quality of life in brain tumor patients: the relative contributions of depression, fatigue, emotional distress, and existential issues. However, spatial resolution of AMT-PET is limited, which makes reliable assessment of detailed tracer kinetics in small regions difficult.
Dietary protein and tryptophan supplementation limit DR-induced memory enhancement The major sources of calories in standard mouse food are carbohydrates, proteins, and fats. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Total protein level was quantified using the Bradford protein assay Bio-Rad.
Acta Neuropathol. A new method to measure brain serotonin synthesis in vivo. Our recent studies with alpha[ 11 C]methyl-L-tryptophan AMT -PET in brain tumor patients indicated abnormal tryptophan metabolism not only in the tumor mass but also in normal-appearing contralateral brain.
Frontostriatal functional connectivity in major depressive disorder. J Nucl Med. Molecular imaging of brain tryptophan metabolism and serotonergic function is a relatively new approach to study cerebral substrates of mood disorders and depression. Prog Brain Res.
They also show that women have lower levels of the protein that transports serotonin back into the nerve cells that secrete it. May 15, Stimulating an inhibitory receptor that decreases serotonin neuron signaling will increase sexual behavior.
Sign up for our email newsletter. I would like to subscribe to Science X Newsletter. There is presumably an increase in sexual activity present, though it appears to hit the ceiling. This is a possible issue to test. And it can put you in a better mood.
This article has been cited by other articles in PMC. When should I consult my doctor? A third possibility for increased tryptophan kinetics in remote brain regions could be the presence of microscopic tumor infiltration, not visualized on MRI. Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6.
The four post-treatment patients had previous resective surgery with or without subsequent chemoradiation. The role of neuroinflammation in brain tumor-associated depression depression could also be further studied by molecular imaging approaches targeting activated microglia, e.